A dRAStic RHOAdblock of Pyrin inflammasome activation
نویسندگان
چکیده
منابع مشابه
Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia.
Burkholderia cenocepacia is an opportunistic pathogen that causes chronic infection and induces progressive respiratory inflammation in cystic fibrosis patients. Recognition of bacteria by mononuclear cells generally results in the activation of caspase-1 and processing of IL-1β, a major proinflammatory cytokine. In this study, we report that human pyrin is required to detect intracellular B. c...
متن کاملThe Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation
Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative bacteria, and secreted T3SS effectors can block key aspects of host cell signaling. To counter this, innate immune responses can also sense some T3SS components to initiate anti-bacterial mechanisms. The Yersinia pestis T3SS is particularly effective and sophisticated in manipulating the production...
متن کاملSite-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation.
Pyrin, encoded by the MEFV gene, is best known for its gain-of-function mutations causing familial Mediterranean fever (FMF), an autoinflammatory disease. Pyrin forms a caspase-1-activating inflammasome in response to inactivating modifications of Rho GTPases by various bacterial toxins or effectors. Pyrin-mediated innate immunity is unique in that it senses bacterial virulence rather than micr...
متن کاملCellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.
Pyrin domain (PYD) proteins have recently emerged as important signaling molecules involved in the development of innate immunity against intracellular pathogens through activation of inflammatory mediator pathways. ASC is the central adaptor protein, which links pathogen recognition by PYD-containing pathogen recognition receptors, known as PYD-Nod-like receptors (NLR), PAN, PYPAF, NALP, Nod, ...
متن کاملActivation of the pyrin inflammasome through the RhoA signaling pathway in FMF and HIDS
Introduction Mutations in the genes encoding pyrin and mevalonate kinase (MVK) cause the autoinflammatory diseases familial Mediterranean fever (FMF) and hyperimmunoglobulinemia D syndrome (HIDS), respectively. The inflammation of both diseases is mediated by interleukin-1b (IL-1b). Recently it has been reported that pyrin forms an inflammasome, a multiprotein complex that mediates the maturati...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2016
ISSN: 1529-2908,1529-2916
DOI: 10.1038/ni.3511